Ba Na-Nui Chua Nature Reserve is centred on Mount Ba Na, a 1,487 metre-high mountain on the border between Da Nang city and Quang Nam province. Mount Ba Na is situated to the south-east of the mountain ridge that stretches across central Vietnam, from the Annamite mountains to the Hai Van pass. However, Mount Ban Na and the montane habitats it supports are isolated from this ridge by intervening areas of lower elevation.
Streams and rivers originating in the north-west of the nature reserve feed the Ca De river, which flows into the north of Da Nang bay, while those originating in the south and east of the nature reserve feed the Yen river, which flows into the south of the bay.